Released on = July 20, 2007, 9:13 am

Press Release Author = AnaSpec Inc.

Industry =

Press Release Summary = This week AnaSpec, one of the world's largest providers of
custom and catalog peptides, introduced eleven (11) new peptides for drug discovery
research.

Press Release Body = July 19, 2007 - San Jose, CA

This week AnaSpec, one of the world's largest providers of custom and catalog
peptides, introduced eleven (11) new peptides for drug discovery research.

MUC5AC; Analog 1 - Cat# 61329, 1 mg
This peptide is derived from the human mucin MUC5AC gene sequence. Data suggest that
MUC5A and MUC5C are part of the same gene MUC5AC; which is distinct from MUC5B. The
gene MUC5AC is mainly expressed in gastric; tracheo-bronchial mucosae and some
tumors; it exhibits two kinds of deduced peptide domains; one of which is 8 amino
acid tandemly repeated domain; a consensus peptide TTSTTSAP.
Sequence: GTTPSPVPTTSTTSAP

[Ile12; Val15] MUC5AC Analog 3 - Cat# 61331, 1 mg
This sequence corresponds to the sequence found naturally in mucin-type MUC5AC
glycoprotein; but with 2 amino acid substitutions - a reflection of mucin molecule
polymorphism. MUC5AC gene is mainly expressed in gastric and tracheo-bronchial
mucosae.
Sequence: GTTPSPVPTTSITSVP

[Ala6; Val15] MUC5AC Analog 2 - Cat# 61330, 1 mg
This is a mucin peptide MUC5AC motif with 2 amino acid substitutions that are a
reflection of mucin molecule polymorphism. Mucin-type O-glycosylation is regulated
by a repertoire of ppGaNTase enzymes; the mammalian UDP-GalNAc:polypeptide
N-acetylgalactosaminyltransferase (ppGaNTase) family. A panel of modified peptides;
including this peptide; is used to detect ppGaNTase activity in vitro.
Sequence: GTTPSAVPTTSTTSVP

MUC5AC-3/13 - Cat# 61332, 1 mg
This is a MUC5AC peptide with two sites (Thr3 and Thr13) labeled with GalNAc where
the asterisk denotes GalNAc-modified residues. Mucin type O-linked glycosylation is
initiated by the action of a family of UDP-GalNAc: polypeptide
N-acetylgalactosaminyltransferases (ppGaNTase); which catalyze the transfer of
GalNAc from the nucleotide sugar UDP-GalNAc to the hydroxyl group of either serine
or threonine.
Sequence: GT-T*-PSPVPTTST-T*-SAP

MUC5AC; Analog B - Cat# 61335, 1 mg
This peptide is a fragment of human mucin 5 containing consensus peptide TTSTTSAP
repeated domains. MUC5AC represents a mucin peptide core expressed in normal gastric
epithelia and some tumors.
Sequence: TTSTTSAPTTS

MUC5AC 3 - Cat# 61334, 1 mg
This peptide is a 16 amino acid modified fragment of mucin 5/MUC5AC; where T* is a
GalNac labeled threonine 3. Mucin-type linkages (GalNAc 1-O-Ser/Thr) are initiated
by a family of glycosyltransferases known as the
UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferases
(ppGaNTases). These enzymes transfer GalNAc from the sugar donor UDP-GalNAc to
serine and threonine residues; forming an alpha anomeric linkage. The MUC5AC gene;
which is mainly expressed in gastric and respiratory mucosae; exhibits 8 amino acid
tandemly repeated domain; the consensus peptide TTSTTSAP.
Sequence: GT-T*-PSPVPTTSTTSAP

Aquaporin-2 (255-271); human - Cat# 61326, 1 mg
This is a fragment of human aquaporin-2 (AQP2); amino acids 255 to 271. AQP2 is one
of the water-channel proteins expressed in principal cells of kidney collecting
ducts; where it is stored in the intracellular compartment.
Sequence: QSVELHSPQSLPRGSKA
Sequence (3-Letter):
H-Gln-Ser-Val-Glu-Leu-His-Ser-Pro-Gln-Ser-Leu-Pro-Arg-Gly-Ser-Lys-Ala-OH

Aquaporin-2 (255-271); rat - Cat# 61327, 1 mg
This is a fragment of rat aquaporin-2 (AQP2). Aquaporins are water channels. They
form pores in the membranes of cells and selectively pass water molecules through
the membrane.
Sequence: QSVELHSPQSLPRGTKA
Sequence (3-Letter):
H-Gln-Ser-Val-Glu-Leu-His-Ser-Pro-Gln-Ser-Leu-Pro-Arg-Gly-Thr-Lys-Ala-OH

Aquaporin-2 (254-267); pSER261; human - Cat# 61328, 1 mg
This peptide is a fragment of the human aquaporin-2 (AQP2) phosphorylated at Ser261.
Protein phosphorylation plays a key role in vasopressin signaling in
renal-collecting duct. Phosphorylation at several AQP2 residues including Ser256
and Ser261; is altered in response to vasopressin. It is possible that both sites
are involved in vasopressin-dependent AQP2 trafficking.
Sequence: RQSVELH-pS-PQSLPR

Aquaporin-2 (254-267); pSER256; human - Cat# 61325, 1 mg
This peptide is a fragment of the human aquaporin-2 (AQP2) phosphorylated at Ser256.
Protein phosphorylation plays a key role in vasopressin signaling in the
renal-collecting duct. AQP2 residues including S256 and S261; are altered in
response to vasopressin. In the presence of vasopressin; AQP2 monophosphorylated at
Ser256 and diphosphorylated AQP2 (pSer256/261) increase in abundance; whereas AQP2
monophosphorylated at Ser261 decreases; suggesting that both sites are involved in
vasopressin-dependent AQP2 trafficking. Aquaporins are water channels. They form
pores in the membranes of cells and selectively pass water molecules through the
membrane; and prevent the crossing of sodium; potassium and other ions and small
molecules.
Sequence: RQ-pS-VELHSPQSLPR

Aquaporin-2 (254-267); human - Cat# 61324, 1 mg
This peptide is a fragment of the human aquaporin-2 (AQP2) which is primarily
expressed in renal collecting ducts and is altered in response to vasopressin via
phosphorylation of several phosphorylation sites. Aquaporins are water channels.
They form pores in the membranes of cells and selectively pass water molecules
through the membrane; and prevent the crossing of sodium; potassium and other ions
and small molecules.
Sequence: RQSVELHSPQSLPR

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